El libro está escrito y editado por una persona afortunada de ver y trabajar a través de la evolución de la medicina de precisión en las últimas tres décadas con contribuciones de expertos en sus respectivos campos. El libro comienza con una introducción a la genómica y la medicina de precisión, seguida de un capítulo sobre secuenciación genómica pediátrica y nueve capítulos centrados en el diagnóstico patológico necesario para las terapias de precisión en el cáncer.
Breve descrição
O livro foi escrito e editado por alguém que teve a sorte de ver e trabalhar a evolução da medicina de precisão nas últimas três décadas, com contribuições de especialistas em seus respectivos campos. O livro começa com uma introdução à genômica e à medicina de precisão, seguida de um capítulo sobre sequenciamento genômico pediátrico e nove capítulos com foco no diagnóstico patológico necessário para terapias de precisão no câncer.
Full description
The book is written and edited by an individual fortunate to see and work through the evolution of precision medicine in the last three decades with contributions from experts in their respective fields. The book begins with an introduction to genomics and precision medicine, followed by a chapter on pediatric genomic sequencing and nine chapters focused on the pathologic diagnosis required for precision therapies in cancer. Tumors of the central nervous system (the brain and spinal cord) and the thyroid and salivary glands are described, including the most up-to-date World Health Organization (WHO) diagnostic pathologic classifications. The importance of the WHO classification of cancer in precision medicine is discussed. For hematolymphoid neoplasms, a detailed historical background for leukemia and lymphoma classifications precedes the description of the 5th edition WHO 2022 classification and its comparison with the International Consensus Classification. Novel techniques in flow cytometry and measurable residual disease detection in hematolymphoid neoplasms by flow cytometry are described with ample illustrations. Other chapters include liquid biopsies in blood cancer, precision diagnosis in the lung, colorectal, ovarian, and prostate cancers, novel immunotherapies in cancer, including essential concepts underlying pathologic testing in cancer, and digital pathology and artificial intelligence as necessary tools for advancing precision medicine.
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